A rare case of inherited disorder with atypical imaging findings – A case report
How to cite this article: Kalekar T, Kumar SP. A rare case of inherited disorder with atypical imaging findings – A case report. Case Rep Clin Radiol, doi: 10.25259/CRCR_36_2023
Gaucher’s disease (GD) is one of the most commonly known which is a progressive, rare hereditary disease, with an autosomal recessive inheritance pattern. It produces a deficiency in the activity of the enzyme beta-glucosidase provoking an accumulation of glucosylceramide in the lysosomes of different cells causing cytopenias, hepatosplenomegaly, changes in the central nervous system, and skeletal manifestations. The viscera most commonly involved with accumulation of Gaucher cells is the liver and spleen. Current recommendation for evaluating and monitoring visceral involvement is volumetric magnetic resonance imaging (preferred due to lack of ionizing radiation) or computed tomography every 12–24 months. Here, we report a case of GD presented with abdominal distension since past 3 months, decreased appetite since past 1 month, and breathlessness since past 1 month.
Enzyme replacement therapy
Lysosomal storage disorders (LSDs) are a collection of several genetic disorders occurred due to the mutation in genes that encode for enzymes involved in the degradation of complex macromolecules. Deficiency of these enzymes results in cellular dysfunction and various clinical manifestations. Of the several known LSDs, Gaucher’s disease (GD) is one of the most commonly known worldwide. It is a progressive, rare hereditary disease, with an autosomal recessive inheritance pattern described in 1882 by Philippe Charles Ernest Gaucher. It produces a deficiency in the activity of the enzyme acid beta-glucosidase (GBA) located on chromosome 1, provoking an accumulation of glucocerebroside in the lysosomes of different cells, causing cytopenias, hepatosplenomegaly, changes in the central nervous system (CNS), and skeletal manifestations, the latter being one of the most disabling aspects.
Depending on the clinical expression, different types can be distinguished: Type 1 (adult non-neuronopathic), the most common form with variable manifestations such as spleen and liver enlargement, bone problems, and fatigue, but not involving the CNS; Type 2 (acute neuronopathic), infrequent, fatal after birth and involvement of the CNS; and Type 3 (subacute or chronic neuronopathic), beginning during childhood, adolescence, or adulthood, with involvement of the CNS.
Type 1 GD has a prevalence of 90–95%, with an invariable clinical presentation that ranges from being asymptomatic throughout the life to early-onset of symptoms in the childhood. Although type 1 GD is not life-threatening, it decreases the quality of life and increases morbidity. Fatigue is very common in children; other symptoms include retarded growth, delayed puberty, splenomegaly, hepatomegaly, and mucocutaneous bleeding.[4-7] Type I GD is more prevalent in Ashkenazi Jewish population. Of all mutations of the GBA, 84 GG insertion particularly occurs in Ashkenazi Jewish and N370S mutation is frequent in these population.
Type 2 GD occurs in less than 2% of cases. The disease manifests itself at a very early stage in the infancy and is associated with severe neurological impairment. Splenomegaly has always been reported, along with thrombocytopenia, growth retardation, lung lesions, and pulmonary infiltration by Gaucher cells. Death is usually reported before the 3rd year of life.[10,11]
Type 3 GD occurs in 5% of cases, with heterogenous phenotypes, ranging from moderate systemic involvement to more severe neurological symptoms such as progressive myoclonus epilepsy, cerebellar ataxia or spasticity, and dementia.[9,12,13] This type has been reported to be more common in young children, with behavioral changes and death reported in few patients.[12,14]
Diagnosis of GD is made on the basis of clinical history, physical examination, laboratory test, and imaging results and confirmed by a blood test showing deficient glucocerebrosidase enzyme and genetic mutation studies when the diagnosis is doubtful. History of consanguinity and family history of suspected or proven GD will support the diagnosis. Here, we report a case of GD presented with massive splenomegaly as the prodromal symptom. The present case is of relevant interest to the scientific community due to its low incidence, which makes it a rarely-suspected diagnostic possibility, leading, not infrequently, to a diagnostic delay, which makes it important for medical personnel in charge of its diagnosis and monitoring.
A 35-year-old female patient came to the department of internal medicine with the complain t of abdominal distension since past 3 months, decreased appetite since past 1 month, and breathlessness since past 1 month. There was no history of hematuria, lithuria, pyuria, frequency, urgency, hesitancy, burning micturition, bowel disturbances, weight loss, loss of appetite, and trauma. No history of IHD or relevant surgeries and addictions was there.
In the department of radiodiagnosis, ultrasound was done, which revealed hepatosplenomegaly and computed tomography (CT) scan was done. CT scan was done in Ingenuity elite 128 slice Philips CT scan machine. Plain and post-contrast contiguous axial CT sections were taken for abdomen and pelvis with oral and intravenous contrast. Routine blood investigations were performed and random blood glucose was 95 mg/dL.
In CT scan, hepatomegaly noted with maximum craniocaudal dimension of 21 cm. There was heterogeneous enhancement of the liver with multiple non-enhancing areas measuring around 8–10 mm in venous and arterial phases with isodense on delayed images in both lobes of liver; some of them were subcapsular in location.
Massive splenomegaly noted with maximum craniocaudal dimension of 32 cm [Figure 1a]. Multiple well-defined areas of low attenuation were noted in the spleen, showing no contrast enhancement. The main splenic vein appeared dilated with normal contrast opacification and splenic artery spears normal at splenic hilum. Few of the areas showed well-defined enhancing wall formation with large central non-enhancing necrotic area [Figure 1b]. It was causing displacement of bowel loops to the right [Figure 1c], stomach anteriorly, and left kidney more posteriorly and inferiorly. Surrounding splenic parenchyma showed few non-enhancing calcified areas with intervening hypodense areas-likely suggestive of old splenic infarcts or Gaucheromas [Figure 1b and c]. Moderate ascites was noted.
The patient underwent spleen biopsy. The histopathology report showed enlarged macrophages in the spleen [Figure 1d]. Magnetic resonance imaging (MRI) could not be performed as patient had metallic implant for the tibia fracture. Chest radiograph was performed and is normal [Figure 2].
Gaucher’s disease results from deficiency of a lysosomal enzyme glucocerebrosidase (also known as acid GBA). The enzyme acts on the substrate glucocerebroside which is a component of the cell membrane. In the normal lysosome, protein saposin C presents glucocerebroside to GBA which activates the enzyme. This enzyme is responsible for hydrolytic breakdown of glucosylceramide to glucose and ceramide. Deficiency of the enzyme leads to accumulation of glucosylceramide and other glycolipids in the lysosomes of macrophages, primarily in the spleen, liver, bone marrow, brain, osteoclasts and less often the lungs, skin, kidneys, conjunctivae, and heart.
The most common signs and symptoms noted in GD are splenomegaly (95%), hepatomegaly (87%), radiological bone disease (81%), thrombocytopenia (50%), anemia (40%), growth retardation (34%), bone pain (27%), and bone crisis (9%). A skeletal manifestation is found more often in older children. Skeletal manifestations include bone infarcts, osteopenia, avascular necrosis particularly of the femoral head, Erlenmeyer flask deformity, and vertebra plana. The viscera most commonly involved with accumulation of Gaucher cells are the liver and spleen. The pulmonary system can be involved as well, although it is very rare. The current recommendation for evaluating and monitoring visceral involvement is volumetric MRI (preferred due to lack of ionizing radiation) or CT every 12–24 months.
Gaucher cells accumulate in the Kupfer cells of the liver, leading to hepatomegaly. Liver volumes in type 1 patients are typically approximately 2 times normal. It is notable that glycolipid does not accumulate in the hepatocytes.[18,19] The Gaucher cells can conglomerate into nodules that can be seen with sonography or MRI. These nodules may be hypoechoic, hyperechoic, or mixed on sonography.[20,21] On MRI, the nodules typically appear isointense or low signal intensity (SI) on T1-weighted imaging (WI) and high SI on T2 WI. Focal areas of extramedullary hematopoiesis can have a similar appearance and can also be seen due the accompanying anemia. Hepatic infiltration can also lead to fibrosis and cirrhosis.
Splenomegaly results from accumulation of Gaucher cells within the spleen. Spleen volumes in type 1 GD are typically 5–15 times normal, but the spleen size can be significantly enlarged in some cases and may be over 50 times normal. Focal splenic masses are common and may represent clusters of Gaucher cells or extramedullary hematopoiesis. They may be detected with sonography, CT, or MRI. Similar to the liver, Gaucher masses in the spleen may be hypoechoic, hyperechoic, or mixed echogenicity.[21,24] On CT, the masses are low density. and occasionally peripherally calcified. These masses are most commonly imaged with MRI. They typically are low SI or isointense on T1WI and high SI on T2WI. Low SI on gradient recalled echo imaging in these masses is thought to be secondary to iron contained in the Gaucher cells. Splenic infarcts can occur as well due to massive splenomegaly and can be detected with imaging as well.
The differential diagnosis of GD is mainly of disease associated with splenomegaly and cytopenia. These would include hematological malignancies and storage disorders like Niemann-Pick. Most of these disorders have characteristic clinical, radiographic, or laboratory features that distinguish them from GD.
|Radiological manifestations of Gaucher’s disease|
|Skeletal manifestations||Bone infarcts, osteopenia, avascular necrosis particularly of the femoral head, Erlenmeyer flask deformity and vertebra plana|
|Visceral manifestations||Hepatomegaly, splenomegaly, splenic infarcts|
|Pulmonary manifestations||Bilateral reticulonodular interstitial pattern|
Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) are the backbone of the management. ERT causes a dramatic effect on organomegaly with a 25% of decrease in liver and spleen volume in first 6 months. Hemoglobin rises by 1.5 g% in the first 4–6 months and platelet counts will double in the 1st year of treatment. However, many patients would still require surgical treatment in the form of splenectomy to correct their pancytopenia. SRT is a newer form of therapy uses agents that will inhibit the enzyme glucosylceramide synthetase and thus decrease the biosynthesis of glucocerebrosidase. One of the major advantages of SRT is its ability to cross the blood– brain barrier and thus improve the neurological symptoms of GD. Advances in the management of this neglected, rare disorder, continue to be hindered by high cost of therapy.
In this case report, hepatomegaly with heterogeneous enhancement of the liver with multiple non-enhancing areas in venous and arterial phases with isodense on delayed images in both lobes of liver, massive splenomegaly with multiple well-defined areas of low attenuation in the spleen with few of the areas, showed well-defined enhancing wall formation with large central non-enhancing necrotic area, surrounding splenic parenchyma showed few non-enhancing calcified areas with intervening hypodense areas likely suggestive of old splenic infarcts/Gaucheromas. The confirmation was done by spleen biopsy. The visceral manifestations in GD respond more quickly usually within a few months or years. Imaging plays a key role in both initial diagnosis and routine monitoring of patient on treatment.
Gaucher’s disease is a rare genetic disorder caused due to deficiency of enzyme beta glucosidase.
Manifestations include hepatomegaly, splenomegaly, bone infarcts, avascular necrosis particularly of femoral head, Erlenmeyer flask deformity and vertebra plana.
GD occurs due to the deficiency of
Answer Key: a
Which is the non-neuronopathic type of GD ?
None of the above
Answer Key: a
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